设为moble365体育投注英超|English Version
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教师内容页
张保军  
研究领域(方向)

实验室从分子、细胞及机体整体水平上,围绕调控T淋巴细胞发育、分化及功能的分子机制方面展开科研工作,主要包括:

(1)解析αβT 、γδT及NKT细胞在胸腺内的早期发育及在外周长期维持的分子机制,阐明各种T细胞亚群如何维持机体完整的免疫系统;

(2)探讨调控效应性与记忆性T细胞分化、维持的分子机制及其在抗感染、肿瘤等疾病中的应用;

(3)研究调控效应性T细胞和调节性T细胞参与自身免疫性疾病发生的机制,寻找治疗自身免疫性疾病的靶点。

个人及工作简历

教授、博导、moble365体育投注英超基础医学院院长

中国西部创新港转化医学研究院院长

国家级青年人才,陕西省领军人才

陕西省科技创新团队负责人

陕西省高校青年创新团队负责人

西安市免疫相关疾病基础与转化重点实验室主任

moble365体育投注英超“青年拔尖人才”A类

 

科研项目

国家重点研发计划项目(子课题)1项

国家自然基金国际合作重点项目1项

国家重点研发计划课题1项

国家自然基金面上项目2项

学术及科研成果、专利、论文

主要业绩

目前在ImmunitySci AdvPNASJ Immunother CancerElifePlos GeneticsJournal of Immunology等杂志上公开发表SCI论文40余篇,共被引用1000余次;担任中国免疫学会理事、陕西省抗癌协会副理事长,器官与系统整合教材-副主编。Frontiers in Cell and Developmental BiologyBMC ImmunologyJournal of Cellular and Molecular Medicine杂志Associated Editor, 担任International ImmunopharmacologyFrontiers in Immunology杂志的编委。

代表性论文

1. Jiao A, Liu H, Ding R, Zheng H, Zhang C, Feng Z, Lei L, Wang X, Su Y, Yang X, Sun C, Zhang L, Bai L, Sun L, Zhang B*. Med1 controls effector CD8+ T cell differentiation and survival through C/EBPβ-mediated transcriptional control of T-bet J Immunol. 2022 (In print).

2. Liu H, Wang X, Ding R, Jiao A, Zheng H, Zhang C, Feng Z, Su Y, Yang X, Lei L, Sun L, Zhang L, Sun C, Zhang B*. The transcription factor Zfp335 promotes differentiation and persistence of memory CD8+ T cells by regulating TCF-1. J Immunol. 2022 (In print).

3. Dong X, Zhang J, Zhang Q, Liang Z, Xu Y, Zhao Y, Zhang B*. Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways. Front Immunol. 2022 Jun 3;13:896472.

4. Ding R, Jiao A, Zhang B*. Targeting toll-like receptors on T cells as a therapeutic strategy against tumors. Int Immunopharmacol. 2022 Jun;107:108708.

5. Liu J, Zhang H, Su Y, Zhang B*. Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases. Cell Biosci. 2022 May 26;12(1):68.

6. Jiao A, Sun C, Wang X, Lei L, Liu H, Li W, Yang X, Zheng H, Ding R, Zhu K, Su Y, Zhang C, Zhang L, Zhang B*. DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms. Sci Adv. 2022 Feb 11;8(6):eabk2691.

7. Wang X, Jiao A, Sun L, Li W, Yang B, Su Y, Ding R, Zhang C, Liu H, Yang X, Sun C, Zhang B*. Zinc finger protein Zfp335 controls early T cell development and survival through β-selection-dependent and -independent mechanisms. Elife. 2022 Feb 3;11:e75508.

8.Zhang C, Lei L, Yang X, Ma K, Zheng H, Su Y, Jiao A, Wang X, Liu H, Zou Y, Shi L, Zhou X, Sun C, Hou Y, Xiao Z, Zhang L, Zhang B*. Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice. J Immunother Cancer. 2021 Oct;9(10):e002809.

9. Yang X, Wang X, Lei L, Su Y, Zou Y, Liu H, Jiao A, Zhang C, Liu J, Li W, Ding R, Zhou X, Shi L, Zhang D, Sun C, Zhang B*. Arid1a promotes thymocyte development through β-selection-dependent and β-selection-independent mechanisms. Immunology. 2021 Dec 18.

10. Lei L, Yang X, Su Y, Zheng H, Liu J, Liu H, Zou Y, Jiao A, Wang X, Zhang C, Zhang X, Zhang J, Zhang D, Zhou X, Shi L, Liu E, Bai L, Sun C, Zhang B*. Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survival signalling. J Cell Mol Med. 2021 Mar 17.

11. Lei L, Zhang X, Yang X, Su Y, Liu H, Yang H, Wang J, Zou Y, Wang X, Jiao A, Zhang C, Zheng H, Zhang J, Zhang D, Shi L, Zhou X, Sun C, Zhang B*. A Genetic Model Reveals Biological Features of Neonatal CD4 Helper Cells Undergone Homeostasis in Mice. Front Cell Dev Biol. 2021,9:659744.

12. Yang X, Wang X, Lei L, Sun L, Jiao A, Zhu K, Xie T, Liu H, Zhang X, Su Y, Zhang C, Shi L, Zhang D, Zheng H, Zhang J, Liu X, Wang X, Zhou X, Sun C, Zhang B*. Age-Related Gene Alteration in Naïve and Memory T cells Using Precise Age-Tracking Model. Front Cell Dev Biol. 2021 Feb 11;8:624380.

13. Yang X, Dai T, Zhou X, Qian H, Guo R, Lei L, Zhang X, Zhang D, Shi L, Cheng Y, Hu J, Guo Y, Zhang B*. Naturally activated adaptive immunity in COVID-19 patients. J Cell Mol Med. 2020, 24(21):12457-12463.

14. Zhu K, He C, Liu SQ, Qu M, Xie T, Yang X, Lei L, Zhou X, Shi L, Zhang D, Cheng Y, Sun Y, Zheng H, Shen X, Li Q, Jiang N, Zhang B*. Lineage Tracking the Generation of T Regulatory Cells From Microbial Activated T Effector Cells in Naïve Mice. Front Immunol. 2020 Jan 17;10:3109.

15. Zhang B*, Jiao A, Dai M, Wiest DL, Zhuang Y. Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. J Immunol. 2018, 201(5):1452-1459.

16. Zhang B, Liu SQ, Li C, Lykken E, Jiang S, Wong E, Gong Z, Tao Z, Zhu B, Wan Y, Li QJ. MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. Immunity. 2016 Mar 15;44(3):568-581.

17. Zhang B, Jia Q, Bock C, Chen G, Yu H, Ni Q, Wan Y, Li Q, Zhuang Y. Glimpse of natural selection of long-lived T-cell clones in healthy life. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9858-63.

18. Zhang B, Wu J, Jiao Y, Bock C, Dai M, Chen B, Chao N, Zhang W, Zhuang Y. Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol. 2015 Nov 1;195(9):4282-91.

19. Zhang B, Dai M, Li QJ, Zhuang Y. Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. PLoS Genet. 2013, 9(10): e1003887.

20. Zhang B, Lin YY, Dai M, Zhuang Y. Id3 and Id2 Act as a Dual Safety Mechanism in Regulating the Development and Population Size of Innate-like γδ T Cells. J Immunol. 2014, 192(3):1055-63.

21. Zeng C*, Shi X*, Zhang B*, Liu H, Zhang L, Ding W, Zhao Y. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med (Berl). 2012, 90(2): 175-86.

22. Duan K*, Zhang B*, Zhang W, Zhao Y, Qu Y, Sun C, Zhao Y. Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells. Transpl Immunol. 2011, 25(4): 173-9. (co-author)

23. Zhang B, Zhang A, Qu Y, Liu J, Niu Z, Zhao Y. Development of mouse CD4(+)CD25(+)Foxp3(+) regulatory T cells in xenogeneic pig thymic grafts. Transpl Immunol. 2009, 20(3):180-5.

24. Zhang B, Duan Z, Zhao Y. Mouse models with human immunity and their application in biomedical research. J Cell Mol Med. 2009 Jun;13(6):1043-58.

25. Javeed A*, Zhang B*, Qu Y, Zhang A, Sun C, Zhang L, Liu J, Zeng C, Zhao Y. The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. Transpl Immunol. 2009, 20(4): 253-60.

26. Zhang B, Sun C, Qu Y, Zhang A, Liu J, Zhang L, Niu Z, Zhao Y. Deficiency of mouse CD4+CD25+Foxp3+ regulatory T cells in xenogeneic pig thymus-grafted nude mice suffering from autoimmune diseases. Cell Mol Immunol. 2008, 5(5): 325-32.

27. Zhang B, Zhang A, Zhao Y. Platelet aggregation and thrombosis in xenotransplantation between pigs and humans. Thromb Res. 2008,121(4): 433-41.

28. Zhang B, Ge B, Xia X, Liu J, Sun L, Rao E, Zhao Y. Compatibility of porcine and human interleukin 2: implications for xenotransplantation. Xenotransplantation. 2006 Sep;13(5):423-32.

29. Zhang B, Guo J, Zhuang Y, He YW, Zhu P, Wan Y, Li QJ, Robins E, Zheng M, Ni Q, Liu S, Liang C. Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage. Cell Mol Immunol. 2021 Jan;18(1):150-161.

30. Ko A, Watanabe M, Nguyen T, Shi A, Achour A, Zhang B, Sun X, Wang Q, Zhuang Y, Weng NP, Hodes RJ. TCR Repertoires of Thymic Conventional and Regulatory T Cells: Identification and Characterization of Both Unique and Shared TCR Sequences. J Immunol. 2020 Feb 15;204(4):858-867.

31. Lei L, Qian H, Yang X, Zhang X, Zhang D, Dai T, Guo R, Shi L, Cheng Y, Zhang B, Zhou X, Hu J, Guo Y. The phenotypic changes of γδ T cells in COVID-19 patients. J Cell Mol Med. 2020 Oct;24(19):11603-11606.

32. Wang Q, Lin YY,Zhang B, Wu J, Roy S, Ratiu JJ, Xu Y, Dai M, Hale LP, Xiong Y, Li QJ, Zhuang Y. A mosaic analysis system with Cre or Tomato expression in the mouse. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28212-28220.

33. Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J, Oberdörfer L, Tan L, Lienenklaus S, Zhang B, Naumann R, Zhuang Y, Krueger A, Förster R, Prinz I. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. J Exp Med. 2018 Dec 3;215(12):3006-3018.

34. Carico ZM, Roy Choudhury K, Zhang B, Zhuang Y and Krangel MS. TCRd rearrangement redirects a processive Tcra Recombination program to expand the Tcra repertoire. Cell Rep. 2017,19(10): 2157-2173.

35. Li J, Roy S, Kim YM, Li S, Zhang B, Love C, Reddy A, Rajagopalan D, Dave S, Diehl AM and Zhuang Y. Id2 collaborates with Id3 to suppress invariant NKT and innate-like tumors. J Immunol. 2017,198(8): 3136-3148.

36. Liu SQ, Jiang S, Li C, Zhang B, Li QJ. miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation. J Biol Chem. 2014, 289(18):12446-56

37. Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zhang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind JS, Chen W. Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol. 2011, 12(1): 14-16.

38.Qu Y, Jin S, Zhang A, Zhang B, Shi X, Wang J, Zhao Y. Gamma-ray resistance of regulatory CD4+CD25+Foxp3+ T cells in mice. Radiat Res. 2010,173(2):148-57.

39.Qu Y, Zhang B, Liu S, Zhang A, Wu T, Zhao Y. 2-Gy whole-body irradiation significantly alters the balance of CD4(+)CD25(-)T effector cells and CD4(+)CD25(+)Foxp3(+)T regulatory cells in mice. Cell Mol Immunol. 2010, 173(2): 148-157.

40. Javeed A, Hou Y, Duan K, Zhang B, Shen H, Cao Y, Zhao Y. Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice. Inflamm Res. 2011, 60(4): 389-398.

41. Zheng Q, Xu Y, Liu Y, Zhang B, Li X, Guo F, Zhao Y. Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice. J Mol Med. 2009 Dec;87(12):1191-205.

42. Aijun Zhang, Yanyan Qu, Baojun Zhang, Lianjun Zhang, Chun Zeng, Xuebing Ji, Ming Hou, Yong Zhao. Effect of indirubin on CD4+CD25+ Treg in mice. J Mol Med. 2007 Nov;85(11):1263-70.

43. Qu Y, Zhang B, Zhao L, Liu G, Ma H, Rao E, Zeng C, Zhao Y.  The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice. Transpl Immunol. 2007 Apr;17(3):153-61.

44. Wang H, Zhao L, Sun Z, Sun L, Zhang B, Zhao Y. A potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice. Transplantation. 2006 Dec 15;82(11):1484-92.

联系方式
电子邮箱:bj.zhang@mail.xjtu.edu.cn
联系电话:18988622636
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更新日期:2022-07-06